Parkinson's: Compound LIST

I need to research the following:
uridine
saffron: (crosses human BBB and 2 other studies for PD in mice)
http://www.ncbi.nlm.nih.gov/pubmed/25163440
http://www.ncbi.nlm.nih.gov/pubmed/25713594

possibly low on other hormones: vasopresin, norepinephrin, TSH
Tauroursodeoxycholic acid (TUDCA)
inositol (scyllo-inositol, raises uric acid?)
rifampicin ( antibacterial for leprosy who did not get PD. upregulates HSP GRP78)
thioredoxin reductase activates thioredoxin and 1 form of it depends on selenocysteine. It upregulates hsp GRP78, IRE1α, TRAF2, JNK, caspase-12, and CHOP

trehalose is a glucose-like sugar used by insects for flynig because it generates more energy. less sweet than gluscose. It also helps cells survive dehydration and helps stabilize a-syn folding at low concentrations.

http://www.ncbi.nlm.nih.gov/pubmed/?term=PMC4496693

It may be broken down too much by trehalase in the GI tract and those missing this enzyme have problems like those missing lactase. http://www.hc-sc.gc.ca/fn-an/gmf-agm/appro/nf-an119decdoc-eng.php

Tyrosine deficiency (amino acid)
metformin is an ancient "increase lifespan" drug for type 2 diabetes that reduces glucose in absorption, liver, and blood (like calorie restriction?)  It binds to a-syn without letting misfold.  It help in PD models of mice.
ritalin binds to a-syn in a way that locks it but does not let it misfold.  
ritalin and metformin: http://www.ncbi.nlm.nih.gov/pubmed/26378986

"Several polyphenols, phenothiazines, porphyrins, polyene macrolides, and Congo red and its derivatives, BSB and FSB, inhibited α-synuclein filament assembly with IC50 values in the low micromolar range. Many compounds that inhibited α-synuclein assembly were also found to inhibit the formation of Aβ and tau filaments."

=== possibly  harmful compounds reported===
milk, chocolate, creatine with caffiene, DHA in fish oil, niacin, manganese of course

I'm going to order the following plant extracts in bulk from China as powders and mix them for storage and later mixing in drinks. 
I'll dump the powders in a 5 gallon bucket, shake, bottle, and label according to FDA.  I'm already taking about 2/3 of them.   Let me know if I'm missing anything.  I take 1 tablespoon of the powder twice a day mixed in a juice/wine.
The dose simulates the animal and test tube research. Doses are between 200 mg and 2000 mg daily doses, but usually 500 mg to 1000 mg twice a day.  So it's the equivalent of 30 pills per day, replaced by 2 bad-tasting drinks. 

List of nutrients to be included in my next batch, not a-Syn blockers
=================
fisetin (strawberries)
apigenin (chamomile, parsley, celery, and in bee products, an MAO-AB inhibitor)
nobiletin (from citrus, may not include if the taste is too bad)
hesperidin (citrus, etc, very common)
Heptamethoxyflavone HMF (citrus)
citicoline (helps memory in AD, dopamine receptors, is bioavailable, neuroprotective, hormones (TSH, GH, TSH)

 a-Syn blockers to be included (bioavailability possible but not known by me):
=======
naringin (the grapefruit bitterness)
gallic acid (from nutgall, black tea, teas, grapes, berries)
myricetin (bayberry bark)
morin (guava, osage)
Nordihydroguaiaretic acid
Genistein (ginseng) (possibly because it is like nobiletin: a TKI)
cuminaldehyde (cumin)
quercetin (apples)

a-Syn non-supplment blockers
========
exercise?  HSP GRP78?
nilotinib (pharmaceutical, primarily by increasing AMPK)
rasagiline? (pharmaceutical)
methylene blue (common chemical, not completely safe)
4-phenyl butyrate (BPA)
rapamycin (immuno-suppressant for organ transplant)
Rifampicin (anti-bacterial for tuberc & leprosy, upregulates HSP GRP78)

Considering:
==========
inosine (raises urate, should not take too much, raises activity of other compounds)
Tangeretin (tangerine, very expensive but requires only 1/5 as much as others)
alpha-lipoic acid
acetyl-L-carnitine
NAC
creatine (this can make PD worse when taken with caffeine)
CoQ10
black tea extract (in case gallic acid is the not the primary benefit)
rutin (like quercetin)
peperine (for increasing bioavailability of some, hot taste will be tough to swallow straight)

Works or may work in PD and advisable in my opinion and not listed above included:
===========
Best evidence: nicotine (causes temporary imbalance and nausea), vitamins A, B's, D, E, fish oil, omega 3's from canola or flax, zinc, magnesium, melatonin, caffeine, 5-HTP, an NSAID like aspirin or ibuprofen, ellagic acid in olive and canola oil.
Whole extracts or foods: blueberry, apple, strawberry, teas, grape seed, beer, sardines.
Others with possibility: Co-Q10, theanine,  selenium. Less evidence for: Mucuna pruriens, fava/broad beans,  Bacopa monnieri, Gotu Kola, Ashwagandha. Bioavailable?  PQQ, resveratrol, curcumin.

Not part of my a-Syn blockers/breakers listed above due to questions about bioavailability
==============
baicalein (skullcap flower, oxidized this breaks up existing a-Syn possibly like no other, seems completely unable to make it past liver to brain)
berberine (not strongly bioavailable, but can be helped with verapamil)
rosmarinc acid blocks a-Syn aggregation, but does not appear to be bioavailable.
resveratrol
curcuminoids
palmitoylethanolamide (PEA) is not orally bioavailable. (increases neurosteroidgenisis, affects cannaboid receptors, reduces inflammation and pain, improves mouse model for PD "Our results indicate that the PEA is neuroprotective even when administered once the insult has been initiated." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422290/)

Pharmaceuticals useful in PD:
===========
L-DOPA, rasagiline, Ritalin, SSRI anti-depressants and wellbutrin (norepinephrine), synthetic triterpenoids, statins, ferriprox (iron chelator for PD), Nilotinib/Bafetinib/Dasanitib ($100,000 per year).  Rifampicin is used in tuberculosis and leprosy and is an a-Syn blocker.  Sirolimus (rapamycin) has been investigated a lot for PD and shows strong effects in animals, 150 pubmed articles. No trials in humans that I saw. It is an immunosupressant used in organ transplant, has a lot of research like mice lifespan extension and cancer cause and cure. It's derivative tacrolimus could also be important, 5 articles.  Trichostatin A , an epigenetic repairer, has been used in mice to negate distant (non-contact) mothering and been used in PD.

Toxic stuff
=========
possibly iron, chocolate, definitely milk (men only?), creatine when taken with caffiene, amphetamines, manganese, possibly high dose vitamin C, possibly DHA

Warnings about drug interactions (not complete).  These will amplify or reduce effects of some drugs by affecting liver enzymes. See the links for which pharmaceuticals are affected. This is more important than "grapefruit" interactions because the doses I want to take are very very high compared to grapefruit.
=================
some compounds require CYP3A4 for oxidation in order to activate the compound, so inhibiting it may also decrease some compounds.  But these compounds NEEDING CYP3A4 will still go by the name "substrate" in Wikipedia which otherwise means they are degraded by it.  Also "inhibitors" are also blocked by it because they are "occupied" instead of making it to the bloodstream.
quercetin: https://en.wikipedia.org/wiki/CYP2C8
piperine, curcumin, baicalein, milk thistle, grapefruit juice: https://en.wikipedia.org/wiki/CYP3A4
quercetin, naringin, naringenin, hesperitin: https://en.wikipedia.org/wiki/CYP1A2 and https://en.wikipedia.org/wiki/CYP3A4
apigenin: https://en.wikipedia.org/wiki/CYP2C9
tangeretin, nobiletin: SULT1A1
quercetin, naringin: SULT1A3 which increases beta(2) agonists (asthma)
quercetin upregulates the CYP3A4 enzyme, so taking it several days can lessen the effect of compounds trying to get past CYP3A4.
Taking peperine, curcumin, naringin, and baicalein at same time can amplify each other.
Blocking CYP1A2 increases rasagiline
http://www.ncbi.nlm.nih.gov/pubmed/26530401

myricetin: vegetables, fruits, nuts, berries, tea, and is also found in red wine. Structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids

references to FULL text articles:
http://www.ncbi.nlm.nih.gov/pubmed/22634381
http://www.ncbi.nlm.nih.gov/pubmed/18258594
http://www.ncbi.nlm.nih.gov/pubmed/21443877

rasagiline, methylene blue, BPA, baicalein
http://www.sciencedirect.com/science/article/pii/S0925443911002250

nicotine
http://www.ncbi.nlm.nih.gov/pubmed/12815102 (full)

nicotine and caffeine
http://www.ncbi.nlm.nih.gov/pubmed/25081642

Grape Seed Extract (gallic acid)
http://www.ncbi.nlm.nih.gov/pubmed/24157371
http://www.ncbi.nlm.nih.gov/pubmed/19221432 (full)
http://www.ncbi.nlm.nih.gov/pubmed/20653511

naringin and rutin
http://www.ncbi.nlm.nih.gov/pubmed/22331747

tangeretin (tangeritin)
http://www.ncbi.nlm.nih.gov/pubmed/23112876

ginseng
http://www.ncbi.nlm.nih.gov/pubmed/24316034

ellagic acid
http://www.ncbi.nlm.nih.gov/pubmed/25247703

heat shock proteins (hot baths and exercise)
http://www.ncbi.nlm.nih.gov/pubmed/15992180

notes:
citrulline: could not find support for it.
========================
UPDATED POST
This is an update of a previous post.  The number of compounds that help in the test tube or mice is overwhelming.  Unfortunately, there is not a standard test to determine which ones erach the human brain and thereby works the best.  But this long list gives a lot of hope for PD: there are many different ways a-Syn misfolding can be prevented, reversed, and cleared out of the cell, so a combination of the right ones would not be a waste, but synergistic.

Previous article:
https://healthunlocked.com/parkinsonsmovement/posts/132541563/compounds-that-prevent-a-syn-misfolding

Here are new ones to add to the list:
===========
nicotine & caffeine ( http://www.ncbi.nlm.nih.gov/pubmed/25081642 )
ritalin
metformin (relatively safe and old anti-diabetic medicine)
rifampicin (anti-bacterial)
trehalose  (like glucose, found in mushrooms http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496693/ )

This last one has 28 articles on it that mention PD, and it's the most recent one I've found. It makes me wonder how many more are out there.

Here are the previous list of "supplements" that help:
=============
naringin (the grapefruit bitterness)
gallic acid (from nutgall, black tea, teas, grapes, berries)
myricetin (bayberry bark)
morin (guava, osage)
Nordihydroguaiaretic acid
Genistein (ginseng) (possibly because it is like nobiletin: a TKI)
cuminaldehyde (cumin)
quercetin (apples)
tangeretin (expensive, from tangerine peel)
olive oil (ellagic acid)
EGCG (green tea extract)
Ginkgolide B (ginkgo)

pharmaceutical-like a-Syn protectors:
=============
nilotinib (pharmaceutical, primarily by increasing AMPK)
rasagiline (pharmaceutical)
methylene blue (common chemical, not completely safe)
4-phenyl butyrate (BPA)
rapamycin (immuno-suppressant for organ transplant)

reduces a-Syn misfolding but probably not bioavailable:
==============
baicalein (skullcap flower, oxidized this breaks up existing a-Syn possibly like no other, seems completely unable to make it past liver to brain)
berberine (not strongly bioavailable, but can be helped with verapamil)
rosmarinc acid blocks a-Syn aggregation, but does not appear to be bioavailable.
resveratrol
curcuminoids
palmitoylethanolamide (PEA)

In a sense, kind of a-Syn misfolding reducers:
=============
exercise (increases heat-shock proteins and ATP energy 24 hr/day)
alcohol (increases ATP energy increases ATP energy for clearance)
water (staying hydrated, dehydration increases a-Syn misfolding)
correcting underlying diabetes (increases ATP energy for clearance)

Reminder of the AD-toxic foods:
=========
possibly iron, chocolate, definitely milk (men only?), creatine when taken with caffiene, amphetamines, manganese, possibly high dose vitamin C, possibly DHA in fish oil