Thursday, September 3, 2015

fats, exercise, oxygen, and parkinson's

Excellent ray peat article:

The fat connection to PD is complicated.  Fish oil may help or harm.
I can't find any article on coconut oil. Strange.

DHA from fish oil migh tbe bad in PD, not good:

Ray Peat has a lot to say (below). I don't know what oil other than cocnut oil he thinks is healthy, raising a big question mark. And he doesn't mention the conflicting data on PD and fish oil, even as n-3PUFA's in general seem to protect.  He also is too prone to believe FDA will block coconut oil due to advertiser's claims.
He says fruits, vegetables, and dairy are low on unsaturated fat.  He says the seed oils are bad.
coconut oil better than unsatured seed oils:
lower cholesterol
lower obesity
better thyroid functioning
more energy
less stress on adrenals
more respiration
better skin youth due to less lipid peroxidation
anti-oxidation effect even on unsaturated fats
does not need carnitine transport system
reduces inflammation
increases immunity
glucocorticoid antagonist
age spots are created by oxidants/antioxidants*unsaturated/saturated oils
UV oxidizes the unsaturated fats
makes animals lean, active, hungry
less B6, vit E, and carnitine needed
prevents hypothyroidism, does not suppress thyroid hormone which allows cholesterol to form healthy progesterone and pregnenolone (pro-myelination, promemery)
brain development in mice better
allows eating of fructose to healthfully increase cholesterol since it decreases cholesterol
prevents liver from creating fat which allows the sugars to be used better thanks to pro-thyroid effect
eats 25 grams a day

unsaturated seed oils
oxidize rapidly in the body
opposite of coconut oil
carnitine oxidizes them in order to transport them
increases cancer
lowers cholesterol only because liver is keeping it for protection
vitamin B6 reduces the damage
damage mitochondria by suppressing respiration
suppress response to thyroid hormone
increases mortality

He has other shocking stuff about fats:
The most highly unsaturated fats, including DHA, accumulate with aging, and their toxic fragments are increased in Alzheimer's disease. 
The most highly unsaturated fats found in fish oil break down into chemicals that block the use of glucose and oxygen.
The ratio of saturated fatty acids to polyunsaturated fatty acids is decreased in cancer. Omega-3 fats promote metastasis.

What are you doing for exercise?  I hate the medical establishment, but so it's 1st recommendation, extensive low-aerobic exercise, seems to be the thing I am most sure of with the strongest benefits. After 3 weeks I got to where my head was not buzzing/dizzy/confused and completely forgot about nicotine and rasagiline. Then I stopped, things returned, and canola mayonnaise seemed to be an impressive patch, along with (clearing throat) CDB.  Also coca leaves with active ingredient are a decent patch in daily life, but there seems to have been a recent crackdown preventing Amazon from selling active forms it.  Again, a stimulant.  A stimulant BTW might increase oxygen usage. The non-oxygen fermentation pathway is about 1/2 the energy per glucose, so if your brain is starved of oxygen and it is using this pathway, then nearby cells are being deprived of glucose and even the injured cells are not getting the right amount of energy, but your whole-body glucose-detection system thinks there is enough glucose.  If there is enough glucose, then breathing does not need to increase, so it's a vicious cycle, even if breathing response is not directly suppressed by lack of dopamine.  OK, so the nearby healthy cells not getting enough oxygen or even glucose are under stress and probably pre-disposed to learning the methods nearby fermentation cells are using. I wonder how well established it is that cells learn from nearby "successful" cells...."successful" in utilizing glucose without oxygen.  So a partial answer might be to switch to a fat-based diet where I think oxygen HAS to be available to use it, and the energy producing process is more efficient per energy input.  So when starved of carbs, eat fat.  Maybe go to bed starved of carbs but full of a fat, and eat a good fat as soon as waking and exercise, if not using oxygen mask or CPAP at night.  They say coconut oil is most easily used, but I'm good on canola and probably olive.  Maybe coconut oil first thing in morning for fast usage, canola before bed due to slower usage. When it comes to medicine, sometimes a lot of little data points with low reliability can lead to a very solid theory that allows you to be very critical and examine conflicting data carefully, conflicting data like "paleo diet did not help PD", if someone has ever made that statement. Maybe fat and exercise are best immediately upon waking so that the effect can be better than measured. So the creatine, vit E, and CoQ10 are all chemical ways of trying to get more blood flow (vit E) or oxygen usage (the others) but they are no good unless the oxygen and fat are present. Similarly, I have seen people rely on many pharmaceuticals and psychologists when all they needed to do was get moving.  Oxygen is a bulk nutrient like calcium or potassium. We need over 1000 grams of it to burn 2000 calories, so it's equal in mass to the food or water we drink. About two oxygen atoms (mw=32) are needed to utilize the energy from 1 carbon atom (mw=12). We exhale the same oxygen atoms as CO2 every minute unlike food and water which take a bit longer. So we obviously need it more consistently, like in the night.
It's possible 80% of PD damage and spreading is occurring in the last 3 hours of sleep, although the CPAP study may not provide support for this. I'll have to look at that more carefully.  Repair and damage minimization can occur as in HBOT, or rather, exercise immediately upon waking.  These detailed and careful lifestyle-changes are exactly where medicine fails.  I retired at age 37 based on this failure in a particular medical condition.
I need to learn more about how fats and different sugars are used in the brain and try to find a way to predispose it to use oxygen-based respiration.  Maybe simply increasing oxygen is the best and only way. 

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